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L-carnitine levels in the seminal plasma of fertile and infertile men: correlation with sperm quality

Only two drugs, Riluzole and Edaravone, are currently available, but their therapeutic effects are limited to the extent that the survival can be extended at most a few months [2]

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IGF-1, on the other hand, works faster but is broken down more quickly

In vitro studies commonly evaluate its influence on intracellular pathways such as PI3K/Akt and MAPK/ERK signaling, which are associated with cellular growth, metabolic regulation, and protein synthesis in laboratory models

Similar to peripheral sensitization, inflammatory mediators play an important role, particularly through microglial activation and proliferation in the DRG and spinal cord following nerve injury