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461 Non-alcoholic fatty liver disease (NAFLD) Alterations of hepatic metabolism are critical to the development of liver diseases, in which the NAFLD is the most common chronic liver disease and is strongly related to metabolic syndrome

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Notably, Org 24,598 has demonstrated the capacity to reduce cocaine self-administration in non-human primates following intravenous administration at 1.0 mg/kg across three experimental sessions, as well as in rodent models at intraperitoneal doses ranging from 3.0 to 7.5 mg/kg, supporting its role in attenuating cocaine-seeking behavior (Achat-Mendes et al

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Ivester, P