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Acknowledgements This study was supported by the Shenzhen Science and Technology Program (Grant Nos

All experiments utilizing these ectopically overexpressed transgenes were performed in nhr-49(nr2041) mutant backgrounds to rule out contributions from the endogenous NHR-49 gene

Upon analysis of the kin-19 RNAi - dependent metabolic response, treated animals lacked the metabolic plasticity that was observed in wild-type or nhr-49(nr2041) animals