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10.1080/15376516.2018.1512693 18 AttarilarS.YangJ.EbrahimiM.WangQ.LiuJ.TangY.et al (2020)
(2) the half-life of the compound must be of sufficient duration to maintain a therapeutic level
Also in NETs, self-DNA is bound to HMGB1 or histones, which prevents its degradation and facilitates its passage through membranes or its active uptake via endocytosis and/or receptor binding
Weve seen this play out with patients who come in after running their own protocols for months
When the shield is down, oxidative stress rises, and cells become vulnerable
