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Data analysis Raman spectra obtained from all samples were processed by a routine cosmic ray removal and were baseline corrected using auto-polynomial of degree 3 (WITec Project Plus software)

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2 Vitamin D metabolism and physiological functions Vitamin D is a fat-soluble prohormone that is synthesized primarily in the skin from 7-dehydrocholesterol under ultraviolet B (UVB) radiation, forming previtamin D, which is then thermally isomerized into cholecalciferol (vitamin D)

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Furthermore, we highlight limitations of the current research on utility of AOXs for treatment of infertile couples and the need for well-designed studies that can bridge the gap between research and practice in this regard