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Therefore, the development of novel and versatile methodologies for modifying AONs with precise control over these critical features remains a significant endeavour 23

The targeted delivery of MK-801 was further emphasized by analysis of the top 20 differentially expressed genes derived from the top five enriched functional terms showing a similar but stronger transcriptional regulation for GLP-1MK-801 in comparison to MK-801 (Fig

10.1038/tp.2017.44 120

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Mechanisms of iron accumulation during ferroptosis Iron is an essential component of biological systems and exists in two biologically relevant oxidation states, ferric iron (Fe 3+ ) and ferrous iron (Fe 2+ ), and functions as a cofactor for several proteins and enzymes that can readily undergo redox cycling