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ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways

doi: 10.1006/cimm.1999.1485

However, compromised GPX4 activitydue to genetic mutations, post-translational modifications, or decreased expressionrenders cells vulnerable to ferroptosis

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Mitochondrial fission in apoptosis

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