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In moderate conditions, this dose is sufficient from the beginning

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In the anabolic methionine cycle, niacin, in the form of NAD, is a necessary co-factor for the enzymes dihydrofolate reductase in the folate/tetrahydrobiopterin cycle and S-adenosylhomocysteine hydrolase (1)

Since no conversion is needed before cell uptake the clinical use of Methylcobalamin is preferred in order to quickly supplement the body