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Adding semaglutide adds redundancy without new pathway coverage

There is evidence of a relationship between lipid metabolism in the brain and the development of AD [55]

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doi: 10.1073/pnas.0906773106

A reduction in expression of proteins like claudin-5 and Occludin involved in the formation of BBB TJs and various markers such as IL-8 and metalloproteinase 1 tissue inhibitor are related to increased BBB permeability, which have been observed in HD patients [114, 115]