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[78] reported that fisetin can ameliorate type 2 diabetes-related vascular aging by targeting the PI3K/Akt/Bcl-2/Bcl-xl axis, promoting apoptosis of senescent endothelial cells, suppressing SASP factors, and enhancing the therapeutic efficacy of metformin, though direct dose equivalence and mechanistic comparisons were not established

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Ann Neurol 42:326334

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During darkness, melatonin is rhythmically produced by the pineal glandconcentrations peak between the hours of 2 a.m

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[DOI] [PubMed] [Google Scholar] 29.Hanigan M.H

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