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Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis

Taliaz D, et al

These are Loss of smell sensations (hyposmia or anosmia) Altered taste sensations Memory decline (Dementia) Neuropsychiatric disturbances (depression, anxiety, hallucinations and psychosis) Constipation Sleep disturbances (inability to initiate or maintain sleep, excessive daytime sleepiness) Restless legs syndrome (RLS), REM sleep behavior disorder (RBD) Urinary problems Orthostatic hypotension Pain Abnormal excessive sweating or salivation Problems with controlling impulse e.g

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Renal, Liver and Heart Histology The renal injury was based on the degeneration of the Bowmans space, glomeruli and proximal and distal tubules