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While it must be converted by the body into active coenzyme forms, its unique molecular structure makes it incredibly valuable in its own right

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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

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Theyre especially beneficial for people who cant get enough B12 through diet or who need fast results

Mov Disord 26:558559 [DOI] [PubMed] [Google Scholar] Santos-Garca D et al (2012) Polyneuropathy while on duodenal levodopa infusion in Parkinsons disease patients: we must be alert