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56 Microvesicles from MM patients have also been found to express functional adenosinergic ectoenzymes that can produce ADO from ATP and NAD + , 57 while treatment in vivo with daratumumab can induce the release of microvesicles expressing CD38, among other molecules such as CD39, CD73, CD203a, PDL1, CD55, and CD59

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The details about the advantages and disadvantages of each route are present in Supplementary 4

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