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glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

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glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

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glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

Finally, astrocytes store brain energy currency in the form of glycogen, which can be mobilized to produce lactate for neuronal oxidative phosphorylation in response to glutamatergic neurotransmission

glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

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glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

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glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

What is interesting here is that transition to D-form results in exposure of a conserved cysteine residue which can be readily modified by thiol modifying reagents N-ethylmaleimide or iodoacetamide (Babot et al., 39 on Complex I subunit ND3, which forms part of the P-module, becomes exposed upon A to D transition and can then be modified by alkylating agents

glutathione lungs asthma Airway homeostasis is altered in children with severe asthma: Evidence for oxidant stress JCI - 15LO1 dictates glutathione

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