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Elevation of Intracholedochal Pressure: Buprenorphine has been shown to increase intracholedochal pressure, as do other opioids, and thus should be administered with caution to patients with dysfunction of the biliary tract

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So far, the best results have been obtained by inhibiting MEK (downstream of Ras), but these results are currently limited to pNF and low-grade glioma

[DOI] [PubMed] [Google Scholar] 183.Hawkes C.H