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In the cuprizone model, NLRP3 expression increases by week 3 and remains high through to week 5 [244]

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MATERIALS AND METHODS Animal subjects All animal experiments were approved by the Animal Subjects Ethics Sub-Committee at The Hong Kong Polytechnic University (PolyU) and all experiments involving animals were performed under a valid license from the Department of Health of Hong Kong government in compliance with the Ordinance and The Code of Practice for Care and Use of Animals for Experimental Purposes of Hong Kong