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With selective effect on both epithelial and even more endothelial tissue damage (maintaining both epithelial and endothelial integrity), it was very safe, and there were no side effects in clinical trials (i.e., used in ulcerative colitis)
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Examples include a man with high occupational stress who saw better progressive motility after an 8-week stress-targeting peptide regimen paired with antioxidant therapy
In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease

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