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In 2010, results from a phase II study of single-agent pazopanib in patients with recurrent or metastatic breast cancer revealed promising activity in terms of disease stability and tolerable adverse events (Taylor et al., 2010)

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For instance, aprotinin is a well-known serine protease inhibitor that has been co-formulated with insulin in thiolated chitosan xerogels, leading to a 70% reduction in enzymatic degradation and a 1.7-fold increase in insulin permeability across human EpiOral models and ex vivo sheep buccal mucosa [101]

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Some people may experience extreme side effects

They are not approved for human or animal use of any kind