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Ju, X., Fan, D., Kong, L., Yang, Q., Zhu, Y., Zhang, S., et al., Molecules , 2021, vol

TMJ injections are used to reduce TMJ pain/inflammation and improve jaw function for individuals experiencing discomfort or limited movement in their jaw joints due to TMD

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AS-IV treatment was found to significantly ameliorate the increase of ROS in the cortex and hippocampal CA1 of T2DM mice, decrease MDA levels, increase SOD activity in T2DM mice, and the Nrf2/Keap1/HO1/NQO1 pathway is the main pathway by which AS-IV reduces oxidative stress after T2DM, which in turn reduces cognitive impairment in T2DM mice (56)

In that context, it is noteworthy that optimal function of stem cells depends on their highly specialized microenvironment, or niche [30, 31], and SASP factors deleteriously affect stem cells by altering this niche [32, 33]

These factors support continued research interest despite the disappointing oral efficacy results