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Mice were never allowed to bear a tumor burden exceeding the maximal tumor size of 1 cm in diameter, as approved by MITs Committee on Animal Care

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Reactive Oxygen Species (ROS)Induced genetic and epigenetic alterations in human carcinogenesis

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According to these evidences, the activation of NF-kB in pinealocytes through immune cells at AD brain results in the activation of Aanat gene, leading to the production of melatonin (Fig