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Preferably, a controlled-release pharmaceutical composition of the invention is capable of releasing a cyclobenzaprine analog into a subject at a rapid onset, so as to maintain a substantially constant or desired pharmacological activity for a given period of time, reduce or remove the effect of food on absorption, and to provide elimination of the drug and metabolites from the body with a reduced terminal elimination phase

doi: 10.1111/j.1651-2227.1994.tb13461.x

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Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo