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In summary, this study demonstrated an improvement in pain with a vitamin supplementation regime inclusive of B12 but did not show improved efficacy with addition of folate [31]
In fact, MOTS-c levels naturally rise during exercise, and giving MOTS-c to mice has been shown to enhance their physical performance (they can run longer on a treadmill)
When choosing the right supplement for you, look for one that is highly bioavailable, such as Methylcobalamin
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Clinical trials involving approximately 900 participants found that the adverse event profile was indistinguishable from placebo for most parameters
