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Assessing the efficacy and mechanisms of Pycnogenol on cognitive aging from in vitro animal and human studies

Aldred EM

Extracts from this plant have shown significant reductions in prostate weight and epithelial cell thickness

Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells

Thus, the degree of lipidome unsaturation can serve as a proxy for ferroptosis sensitivity in different cell types and populations

By using different gene set collections such as Tox action, Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene ontology (GO) Biol process, findings show that cyclosporine affects several biological processes including apoptosis, DNA repair, oxidative phosphorylation, endoplasmic reticulum stress, and oxidative stress (Schmeits et al., 2015)