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Macrophages absorb TMAO molecules by binding to specific receptors on their surfaces, which activates internal signaling pathways that induce cholesterol metabolism genes
The synthesis of TMAO and crotonobetaine is strongly reduced by the administration of antibiotics, thus demonstrating that the intestinal microbiota plays an essential role in their synthesis
37 studies with 44 effect sizes were included in this systematic review and meta-analysis (Table 1(Tab
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