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Model 3 further adjusted for smoking history and alcohol consumption history, yielding ORs (95% CIs) of 2.08 (1.094.16) for Class 2 and 2.65 (1.285.67) for Class 3

Altogether, vanin-1 has an atherosclerotic effect, increasing the risk of cardiovascular diseases

The TPH2 gene is located on chromosome 12q21.1 and is composed of 13 exons that encode a protein (tryptophan 5-hydroxylase 2) of 490 amino acids

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J Pharmacol Sci 102:269277 Dobric I, Drvis P, Petrovic I, Shejbal D, Brcic L, Boban Blagaic A et al (2007) Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157

However, many consider the enhanced absorption benefits to outweigh this inconvenience