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Lower IGF-1 Levels correlate with liver dysfunction, fibrogenesis, and mortality in ACLD, primarily through disrupted bone remodeling, marked by reduced osteoblast activity and prolonged osteoclast lifespan[28,29]

Krishnaveni M, Pugalendi KV, Mohan S, Rani M, Doss CGP, Rajasekaran A, et al

Meta-analyses evaluating trials of berberine for dyslipidemia suggest improved lipid profiles, although many studies were heterogeneous, of low quality, or had a high risk of bias (11) (12) , and a review indicates the magnitude of effect to be small (13)

ITCs do not only seem to lead to a heat stress response in plants as it has been shown that 4-methylsulphinylbutyl-ITC (sulforaphane) activates a heat shock response in animal cells [121]

Jianguo Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers