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They can trigger several pro-metastatic signaling cascades, including the NF-B pathway [84], which regulates genes related to cell survival, proliferation, and metastasis, and MAPK pathways that influence cell proliferation, survival, and migration [82]
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Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats
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2.3.1 Iron-based nanoparticles A variety of iron-based nanoparticles have been shown to reedit M2 TAMs to M1 TAMs, such as iron in superparamagnetic iron oxide nanoparticles (SPION) that can induce the transformation of human monocytic leukemia cell (THP1)-derived M2 macrophages to a high CD86+, tumor necrosis factor- (TNF-) positive M1 macrophage subtype (32)
