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Strand breaks can be measured by the alkaline unwinding procedure, based on the discovery that double-stranded DNA (dsDNA) unwind in an alkaline solution from free ends

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The corresponding decrease in asymmetric dimethylarginine (ADMA), a competitive inhibitor of the enzyme that produces nitric oxide, provides a plausible biochemical mechanism for this improvement

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Applied geography 31 , 495507 (2011)