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Parch et al., 2016)

A summary is presented in Table 1 and will be discussed in this section

For example, MBP-1, ECP, or EPO application to airway epithelium in primates produces ciliostasis, desquamation, and hyperreactivity of respiratory smooth muscle mimicking the pathology of asthma.73,74 Damage to endothelium in eosinophilic endomyocardial disease is thought to be the initiating factor in the cardiomyopathy observed in the hypereosinophilic syndromes (see Chapter 36).75 All four of the cationic granule proteins [(1) EPO, (2) ECP, (3) EDN, and (4) MBP-1] likely contribute to the edema observed in skin diseases due to their vasodilatory effects with contribution from mast cells and basophil histamine release by MBP-1.76 Eosinophil granule proteins stimulate various cells in addition to mast cells and basophils, including neutrophils and platelets

doi: 10.1016/j.freeradbiomed.2007.03.024 [DOI] [PMC free article] [PubMed] [Google Scholar] 93

Structurally, Selank comprises tuftsin at the Nterminus fused to a ProGlyPro (PGP) tripeptide at the Cterminus
