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Furthermore, depletion of glutathione, the most abundant low-molecular-weight antioxidant, has been reported in the epithelial lining fluid (ELF) of IPF, sarcoidosis, and HP patients 14,15,16,17,18

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This intricate cascade is further orchestrated by E3 ligases, ultimately culminating in the proteolytic degradation and subsequent recycling of targeted proteins (105,106)

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