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You can take steps to control an infection, or start new plants if you need to

Headache: Commonly observed at higher doses, manifesting as mild pressure, linked to vascular changes

The cuprizone-containing pellets were formed using cuprizone powder from the same batch as that delivered directly to the mice, to minimise any batch or supplier variability

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Confirm the diagnosis through appropriate laboratory tests

Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease