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For example, studies on the intestinal flora of patients with prehypertension and hypertension have found that the most significant characteristics are the reduction and uneven distribution of microbial diversity and abundance, mainly manifested in the increase of Firmicutes / Bacteroidetes ratio, the decrease of probiotics, and the increase of Prevotella and Klebsiella (26)

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Nutrients 11 , 1806 (2019)

Here, we discuss the relationship and related pathophysiologic mechanisms between TMAO and AS, as well as the potential therapeutic strategies that target these pathophysiologic mechanisms