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Since circRNAs are widely distributed in gametes and embryos, these molecules are probably impacted by these processes

Jan 24 2022;12(2)doi:10.3390/biom12020197 obo P, Regulska-Ilow B

Research shows that in senescent cells, p53 levels are maintained low through ubiquitination while its pro-apoptotic activity is repressed through nuclear segregation by FOXO4. The peptide's competitive inhibition restores p53 activity by promoting nuclear exclusion, allowing p53 to execute its pro-apoptotic program and eliminate senescent cells through targeted pathway activation

The human clinical trial data is thinner

The Journal of Clinical Investigation 56 (5): 11251131

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