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Specifically, the levels of TNF-, IL-1, IL-6, IL-10, IL-2, and IL-12 SOD, CAT, GSH-Px, and MDA were modulated in rats with colitis, also inhibiting TLR4/NF-B pathway activation [175]
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H3R, which is densely localized in histaminergic neurons, functions as an autoreceptor and modulates the release of histamine and other neurotransmitters such as GABA, glutamate, acetylcholine (ACh), and norepinephrine (NE)
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The animals were kept under standard conditions
They help to add specific nutrients like vitamin B12 when intake from food sources is not enough
