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The local population of these isolated islands is of northern European ancestry and therefore expected to have a relatively high prevalence of MS if genetics played a dominant role
However, long-term exposure to water in the oral cavity could potentially accelerate its degeneration due to the solubility of BG
Such an alteration in miRNA-mediated post-transcriptional regulation of gene expression could have a broad impact in cells, including in the negative regulation of ATXN3 expression itself, as the 3 UTR of human ATXN3 is targeted by miRNAs
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