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(2022) showed that FITC-dextrans 70 kDa exhibited negligible passive permeation across porcine esophageal mucosa (buccal model), but co-administration with sodium taurocholate or caprylic acid significantly increased permeability, enabling transmucosal delivery of high-M.Wt dextrans [70]

Here is what researchers most often study, all in animal or cell models: Cytoprotection: Much of the early work looked at how the peptide affects the stomach and gut lining in rodents

The initial administration was given, code 96365

The longer circulation time is the technical reason for the ~6-day half-life and once-weekly dosing

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Yoshikawa, T., Ueda, Y., Miyazaki, K., Koizumi, M