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Mitochondrial dysfunction reduced NAD+ production, and inflammation, including neuroinflammation, are likely contributors to the phenotypes of these conditions (Tate et al., Conclusion The SARS-CoV-2 pandemic has contributed to a dramatic rise in cases of ME/CFS, underscoring the pressing need for robust and sustained research into chronic conditions such as ME/CFS, FM, and GWS

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doi: 10.1038/s41591-020-1051-9

Vitamin B12 is not known to interact with any medications taken specifically for RA