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Frataxin deficiency promotes endothelial senescence in pulmonary hypertension

CD8 + T cells, activated by APCs via MHC class I molecules, differentiate into cytotoxic T lymphocytes (CTLs), which eliminate pathogen-infected or tumor cells through the release of perforin and granzymes [34, 35]

Aging can be caused by both genetic and external factors, such as incorrect diet, improper physical exercise, chronic drug use, untreated inflammatory conditions, smoking, and alcohol abuse

The data robustly suggest that despite its role in reducing the ERs GSHpool, CHAC1 does not influence the UPR, implying that GSHdepletion alone may not be sufficient to disrupt protein folding homeostasis to a degree that activates the UPR

Glutathione plays a crucial role in supporting the immune system by enhancing the function of immune cells

Persulfides, formed through H 2 S reaction with protein cysteine residues or disulfide bonds, possess stronger nucleophilicity and reducing capacity than thiols (RSH), with significantly lower pKa values (46 vs