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Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/-TrcP/Nrf2 pathway

The primary outcome of the study was the difference in total lesion count between the study agent group versus the placebo group from baseline to endpoint

Upon insertion, it dissolves or melts, releasing the medication for local or systemic absorption