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Description: Glutathione is often referred to as the master antioxidant your bodys ultimate detoxifier, immune booster, and cellular protector

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Methods In this study, we design a two-in-one ferroptosis-inducing nanoplatform using iron-based metal-organic framework (MOF) that combines iron supply and GPX4 deactivation by loading the small molecule buthionine sulfoxide amine (BSO) to block de novo GSH biosynthesis, which can achieve sustainable GSH elimination and dual ferroptosis amplification

Glutathione (GSH) is a tripeptide (gamma-L-glutamyl-L-cysteinylglycine) that is found in all mammalian tissues and is especially concentrated in the liver...