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When the FDA places a peptide in a restricted or high-risk category [known as Category 2], it is explicitly signaling that it has identified safety concerns and that enforcement discretion does not apply. But, as Hajduczok notes, just because something is not FDA-approved doesnt mean its illegal to compound, but the restricted peptides should not be compounded

N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease

Gudi et al., 2011)

Since patients are adept at disguising and denying the symptoms of trichotillomania, the condition may go on for years without detection or treatment