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TAC surgery was associated with the upregulation of the hypertrophic cardiomyocyte biomarkers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and -myosin heavy chain (-MHC), whereas these levels were significantly decreased in cardiac tissue samples from PQQ-treated mice that underwent TAC surgery (Figure 1J)

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Compound 2 (5.4 g, 9.72 mmol), H-Lys(Boc)-OMeHCl (3.46 g, 11.52 mmol), HATU (7.42 g, 19.44 mmol) and HOAT (2.64 g, 19.44 mmol) were dissolved in DMF (80 mL) under nitrogen atmosphere and ice bath conditions