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GPx4 uses GSH as a reducing substrate and converts it into oxidized form, also referred to as glutathione disulphide (GS-SG) ( NFE2L2 gene) (Habib et al., 2015), the xCT mRNA can be positively regulated by the activation of transcription factor 4 (ATF4) under oxidative stress (Sato et al., 2004), while its negative regulation by p53 results in cysteine deprivation and increased susceptibility to ferroptosis (Jiang et al., 2015)

Funding The use of REDCap and the work of Patrick Schnell was supported by the Ohio State University Center for Clinical and Translational Science, CTSA Grant UL1TR002733

A Markov model incorporating age, sex, type 2 diabetes (T2D), hypertension was used to generate individualized, time-updated risk trajectories and probabilities of LREs/death

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Jaboska-Ry, E., Skrzypczak, K., Sawiska, A., Radzki, W., & Gustaw, W