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This occurs by the activation of signal transduction pathways involved in the control of transcription of GCLC and GCLM genes but also there is some evidence of mRNA stabilization by oxidants and electrophiles (Liu et al., 1998)

We also found that the number and size of glucagon granules were markedly increased in cells isolated from GCGR-KO mice (Fig

M.Santana SantosV
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doi: 10.1371/journal.pone.0206536 40 DuttaS.HornungS.KruayatideeA.MainaK
