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10.1007/s10620-016-4432-7 [DOI] [PubMed] [Google Scholar] 25.Haghighat M, Rafie SM, Dehghani SM, Fallahi GH, Nejabat M

We also look forward to further advances in approaches to judge and quantify metabolic phenotypes in human breast cancers in vivo , including metabolomics, metabolic imaging and isotope tracing studies, so that clinical oncologists will develop treatment strategies by matching the treatment to the patient-specific tumor metabolic characteristics

Furthermore, identification of defects along the TCA and Glu-Gln pathway may yield specific targets for pharmaceutical interventions

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One example is the use of self-assembling lysosomotropic nanoparticles formed from the combination of the potent autophagy inhibitor Lys-05 and the detergent MSDH, resulting in improved pharmacokinetics and superior antitumor efficacy in preclinical models

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1 induction in response to hypoxic stress and growth factors