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Nrf2 critically interacts with the co-factor PGC-1, operating in the mitochondrial biogenesis perpetuating a regulatory loop, as suggested by Gureev et al [263]

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Mo Med (2020) 117:5368

Randolph, H
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Typically, NMN is converted into NAD + via NMN adenylate transferase (NMNAT), which plays a key role in biological regulation and is an important therapeutic target (Fig