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C.BoehmerL

however, the intracellular calcium overload induced by its activation is a crucial mechanism of apoptosis 172 (Fig

Under hypoxia, tumor cells express various angiogenic factors, such as vascular endothelial growth factor (VEGF), by activating HIF proteins (Xia et al., 2007)

[DOI] [PMC free article] [PubMed] [Google Scholar] 346.Hassan A, Hunt BJ, OSullivan M, Bell R, DSouza R, Jeffery S, Bamford JM, Markus HS

However, the structure of GOAT is yet to be determined, and the active site and substrate-binding sites of the enzyme remain unidentified (32)

Therefore, dimethyl fumarate inactivates GAPDH and inhibits aerobic glycolysis in activated CD4 + T cells, which explains its immunomodulatory role in treating autoimmune diseases, such as multiple sclerosis and psoriasis
