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peripheral inflammation upregulates the expression of COX2 in the spinal cord (Ichitani et al., 1997
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Second, clinical translation should involve establishing multicenter biobanks for preterm infants to validate associations between ferroptosis biomarkers (such as cerebrospinal fluid ACSL4 levels and MRI-detected white-matter iron deposition) and motor development scores (GMFM and Bayley scales)
