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As the greatest division of the autonomic nervous system and rivalling the spinal cord in terms of complexity, ENS components form integrated circuits which independently or in concert with extrinsic parasympathetic and sympathetic innervation regulate a myriad of gut processes including bowel motility, transmucosal movement of fluids, immune responses, and local blood flow [2]

Metabolic reprogramming mainly occurs in the mitochondria and cytoplasm, which refers to the metabolic changes made by cells in response to various stimulus pressures

Whereas vagal nerve stimulation is commonly used in refractory epilepsy patients [100], an increasing number of patients receive intracranial DBS [101]

Sikiric et al., 2012

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Front Chem 9:694998 Sagerfors S, EjdervikLindblad B, Sderquist B (2020) Infectious keratitis: isolated microbes and their antibiotic susceptibility pattern during 20042014 in Region rebro County, Sweden