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In the REDEFINE 1 trial, 79.6% of combination participants experienced GI events versus 39.9% on placebo

From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors

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Combining these two factors can create a particularly uncomfortable experience and may make it harder to tolerate your medication during the critical early adjustment phase